Fig. 1Body
The body, read in sections.
A plastic surgeon sees the body in layers and in cross-section. Three decades of reconstructive and aesthetic surgery start from that map; the regenerative work starts at the donor site.
Prof. Dr. H. Eray Copcu, MDPlastic, reconstructive & aesthetic surgery
Access to the inaccessible.
Regenerative surgery with what the patient already has. The stromal cells in their own fat and the signals in their own blood, freed by blades and screens instead of enzymes, in one operative session.
The method, step by step
Fig. 2Layers
Under the skin, every layer differs.
Epidermis, dermis, the fat close to the surface and the fat that lies deep. Each needs a different graft, and some carry the cells that repair it.
Fig. 3MEST
Cut by blades, not enzymes.
Mechanical Stromal-cell Transfer frees the regenerative cells in a patient's own fat with ultra-sharp blades and calibrated screens. No enzymes, no culture, one session.
Fig. 4TOST
Total stromal cells, not SVF.
What passes the screen is neither SVF nor nanofat but every stromal cell with its matrix. Copcu named it TOST, so results could be compared between studies.
Fig. 5Plasma
The same principle, in blood.
His PvRP kit, patented in 2023, concentrates platelets beyond standard PRP. Mechano-Native Plasma, now in development, aims to keep plasma liquid without anticoagulant by controlling where fibrin forms.
Fig. 6ARAT
One harvest, sized to each site.
Adjustable Regenerative Adipose-tissue Transfer cuts the same fat for the place it will fill: 400 µm or finer around the eyes, thicker grafts for deeper planes, up to 4000 µm for the breast.
Fig. 7Record
Defined, patented, published.
Professor of plastic surgery since 2011, founder of two university departments and of the first regenerative medicine department in a Turkish university.
